Biological databases play a central role in bioinformatics. An important resource for finding biological databases is a special yearly issue of the journal Nucleic Acids Research (NAR). These databases may be public or private. A protein database is one or more datasets about proteins, which could include a protein’s amino acid sequence, conformation, structure, and … Bioinformatics is the branch of science in which we use computer tools and algorithms to analyze biological data. are no longer published in a conventional manner, but directly submitted to databases. Why biological databases ? A biological database is a collection of data that is organized so that its contents can easily be accessed, managed, and updated. Originally they were just sequence collections, but they have grown to store different biological databases heavily interconnected and they provide powerful interfaces to search and browse the stored information. Its mission is to make life science research more efficient and reproducible by curating and hosting high-quality, experimentally validated, freely accessible protocols. Biological databases constitute the data layer of molecular biology and bioinformatics and are becoming a central component of some emerging fields such as clinical bioinformatics, and translational and personalized medicine. INTRODUCTION TO BIOLOGICAL DATABASES SARFARAZ HUSSAIN Department of Bioinformatics & Biotechnology GCU- Faisalabad NOTE: Most slides derived from NCBI’s field guide / sarfraz1412@gmail.com 2. • Essential tools for biological research. Biological databases offer access to a wide variety of biological data and play a central role in bioinformatics56 7. Bioinformatics is an integrated interdisciplinary field it includes various subjects such as math, chemistry, genomics, proteomics, etc. Biological databases play a central role in bioinformatics. The importance of biological databases in biological discovery. Statistical analysis of the data is central to this assessment. The distinction between the concepts of biological relevance and statistical significance should be Bioinformatics has its importance in the management and collection of biological data. Nucleic Acids Research Database Issue. They offer scientists the opportunity to access a wide variety of biologically relevant data, including the genomic sequences of an increasingly broad range of organisms. A DNA database is a stored set of genetic profiles that can be used for a variety of needs. EMBnet MCB, feb 2005 Distribution of databases Confusion in the use of words such as “significance”, “relevance” and “importance” can therefore hinder the assessment. • Data (genomic sequences, 3D structures, 2D gel analysis, MS analysis, Microarrays….) assessment of the evidence provided by these studies. Protocol Online protocol-online.org. 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